Should a prolonged INR in liver cirrhosis be routinely corrected with FFP prior to invasive procedure?
No. PT or INR is not a reliable predictor of bleeding tendency in cirrhotic patients.
Platelet < 50,000/uL or fibrinogen < 120 mg/dL is more reliable than PT or INR in predicting bleeding risk in cirrhotic patients. Targeting INR or PT alone leads to overuse of FFP.
Vitamin K replacement usually has a minimal effect. The thinking has been that “it does not hurt and may help,” so there is no harm in adding vitamin K supplementation to the treatment program.